The capsule for Plenity is made with gelatin, which is a porcine-derived product. Some mixtures of medications can lead to serious and even fatal consequences. Available for Android and iOS devices. First, if you experience a severe or long-lasting side effect or a Plenity has not been studied in people under the age of 22. eCollection 2022 Jun. Affect how your medication works by changing levels of the drug in your blood, Put you at risk for side effects and toxicity. Most drug interactions are not serious, but because a few are, it is important to understand the possible outcome before you take your medications. All available studies were considered. If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents. This is due to lack of specificity of the screening tests. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you cannot use the above website or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985. *If a pre-meal dose is missed, take Plenity during or immediately after that meal. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. It wasnt restrictive. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. All rights reserved. 2021 Dec 7;8(3):363-370. doi: 10.1002/osp4.574. The overall incidence of side effects with Plenity was no different than placebo. FDA Approved: Yes (First approved April 12, 2019) It's always best to ask your healthcare provider for the latest information on drug interactions. An official website of the United States government. How can I get Plenity? You do not need to meet with a physician in person to get Plenity! Call your doctor for medical advice about side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Gelesis Granted FDA Clearance to Market Plenity - a New Prescription Aid in Weight Management. The water oral superabsorbent hydrogel; preobesity; weight management. As an alternative option to current pharmacological AOTs, OSH may address an existing clinical gap in weight management. doi: 10.2196/40062. The overall incidence of side effects with Plenity was no different than placebo. No. This product's label may have been updated. This action works to create increased bulk, thus signaling satiety. Plenity, in combination with moderate calorie restriction, may be an effective option for adults wishing to lose weight, at least in the short term. These medications may cause some risk when taken together. Pricing shown online or via the Inside Rx app are subject to change in real time. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. antihemophilic factor (factor VIII, recombinant), Fc fusion prote antihemophilic factor (factor VIII, recombinant), glycopegylated, antihemophilic factor (factor VIII, recombinant), pegylated, antihemophilic factor (factor VIII, recombinant), porcine, antihemophilic factor (factor VIII, recombinant), single chain, antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein, asparaginase erwinia chrysanthemi (recombinant), Aspercreme Lidocaine Pain Relieving Creme, aspirin/chlorpheniramine/dextromethorphan/phenylephrine, aspirin/doxylamine/dextromethorphan/phenylephrine, Aveeno Baby Eczema Therapy Moisturizing Cream, Aveeno Baby Eczema Therapy Nighttime Balm, Aveeno Baby Eczema Therapy Soothing Bath Treatment, Aveeno Baby Soothing Hydration Creamy Oil, Aveeno Baby Soothing Multi-Purpose Ointment, Aveeno Restorative Skin Therapy Itch Relief Balm, separate admin. A Randomized, Double-Blind, Placebo-Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss. Plenity should be kept in its original pod until use. The result can be muscle pain, or even severe muscle injury known as rhabdomyolysis. Save up to 80% on brand & generic medications. Review the Medication Guide, prescription information, warning labels, and Drug Facts Label with each new prescription or OTC product. This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor. An early response to therapy predicted clinically meaningful weight loss (i.e., 5% or more) at 24 weeks.2. from all oral drugs, esp. Original dose should be taken when co-administered with PRISTIQ 100 mg or lower. Get everything Plenity offers for just $1.75 per meal. Plenity is administered in the form of capsules taken with water before lunch and dinner. OSH offers a nonsystemic approach to weight management for patients who are diagnosed with overweight or obesity. Youll have an answer within 24 hours. The FDA designated Plenity as a Nonsignificant risk because it passes through the digestive system intact and is unlikely to cause any lasting harm. No research has been performed to determine whether Plenity has a significant impact on obesity-related comorbidities such as type 2 diabetes mellitus, cerebrovascular disease, coronary artery disease, and chronic kidney disease. Do not stop your medication without talking to your healthcare provider first. How often a drug interaction occurs, and your risk for a drug interaction, also depends upon factors such as: Don't forget that alcohol, caffeine, and illegal drugs of abuse can lead to serious drug interactions, too. This third-party website is neither owned nor controlled by Pfizer, and Pfizer does not endorse and is not responsible for the content or services of this site. Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion Powe Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy & Cough. This information is currently not available for this drug. Find your topic by using the A-Z list (select a letter). Rather, the hydro-gel capsule releases gel particles containing cellulose and citric acid that absorb water in the stomach and small intestine, expanding significantly in size. If you miss a pre-meal dose, take Plenity with 16 oz. Accessibility In fact, most people will feel fuller after meals and between themhelping you eat and snack less. If you have a caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Other drugs may interact with Plenity, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medications including any supplements you are taking. Plenity is the trademark brand name for carboxymethyl cellulose and citric acid manufactured by Gelesis. 2023 Inside Rx, LLC. These highlights do not include all the You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at. Plenity is not absorbed into the bloodstream. This content is owned by the AAFP. 2005 - 2023 WebMD LLC. Plenity is the first and only FDA-cleared weight management tool made from naturally derived building blockscellulose and citric acid. This is not a complete list of side effects and others may occur. Plenity is NOT available at retail pharmacies. As with other treatments, weight loss with Plenity can vary widely, Leider noted. Find out everything you need to know about weight loss drugs in our prescription weight loss pill guide. To report an adverse event related to Pfizer-BioNTech COVID-19 Vaccine (also known as COMIRNATY, COVID-19 mRNA, Vaccine BNT162b2 or BNT162) or Pfizer COVID-19 Treatment (also known as PAXLOVID (nirmatrelvir tablets; ritonavir tablets)), and you are not part of a clinical trial* for this product, click the link below to submit your information: *If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site. If you use any over-the-counter (OTC) medicine, including vitamins, herbal or food supplements, be sure to review these products for interactions with your prescription medications, too. Plenity has been shown to be effective, safe and well-tolerated in clinical studies. Only FDA approved with a BMI from 25 to 40. Their average weight loss was 10% (about 22 pounds). This tool explains what the interaction is, how it occurs, the level of significance (major, moderate, or minor) and usually a suggested course of action. + There were no serious adverse events (SAEs) in the Plenity treatment group, whereas there was one (1) SAE in the placebo treatment group. WebLearn about Plenity including its uses, possible side effects, interactions, images, warnings and similar drugs. I could still eat the foods my family was eating, and still make progress toward my weight. Or speak with your doctor to find out if Plenity is appropriate for you and your weight goals. Drugs Comparison A-Z List. No gimmicks, just science-backed resources to help support your weight management journey. The site is secure. Inside Rx is administered by Inside Rx, LLC, 1 Express Way, St. Louis, MO 63121 . Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity. If you are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide, you should not take Plenity. Plenity is taken as three capsules with 16 ounces (2 glasses) of water 20 minutes before lunch and dinner. It is currently approved by the U.S. Food and Drug Administration. These side effects include: Stomach pain or upset stomach Oily discharge from the anus Gas with oily anal discharge Oily stools More-frequent bowel movements Urgent or hard-to-control bowel movements Other possible side effects include: Headache Back pain Common cold Contact a doctor right away if problems occur. 2012 Dec 12;12(12):CD008650. Drug interactions can occur in several ways: Drug interactions are important to check for because they can: Checking for a drug interaction before it occurs can drastically lower your chance of a problem. Last updated by Judith Stewart, BPharm on May 13, 2019. Many people begin to lose weight within the first four weeks of taking Plenity. It undergoes rigorous internal medical review and is updated regularly to reflect new information. settings and refresh the page. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Things to remember when you fill your prescription. $98/4-week supply. False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been reported in patients taking desvenlafaxine. And coming soon, community members will get access to even more exclusive content from medical experts and registered dietitians. However, if you discover you are at risk for a possible drug interaction, call your doctor or pharmacist as quickly as you can. Concomitant use of PRISTIQ is contraindicated: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue. Company: Gelesis Save 15% when you purchase a 12-week supply ($249/$1.48 per meal). We comply with the HONcode standard for trustworthy health information. monograph. The released water is reabsorbed in the large intestine, and the remaining cellulosic material is expelled in the feces. Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E. Cochrane Database Syst Rev. Metabolic enzymes in your body and your genetics. For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician. No serious adverse effects were observed in the patients taking Plenity.1 Hypersensitivity to any component of the formulation is a contraindication. WebBlood levels of an interacting drug may rise, leading to toxicity. NCI CPTC Antibody Characterization Program. Submit a medical question for Pfizer prescription products. Unable to load your collection due to an error, Unable to load your delegates due to an error. Plenity may interact with other oral medications taken at the same time. Abstracts and posters were identified from relevant scientific congress archives and published supplements. Bethesda, MD 20894, Web Policies Disclaimer. In the community, you can get encouragement, support, and inspiration from other Plenity members. Some medications may be better absorbed if taken with food or may have more favorable blood levels if taken with other medications that affect metabolic enzymes. disable JavaScript, also known as "Active Scripting". However, as a medical device, Plenity has not been held to the same standard of testing as would be expected with medications. Plenity is not indicated for anyone under the age of 22. of water during or immediately after your meal. Taking a medication that was prescribed for someone else or bought off of the Internet can be dangerous, too and lead to unexpected drug interactions. metformin, monitor glucose: combo may decr. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor. It has been cleared by the FDA for adults. 2023 Gelesis, Inc. All rights reserved. Shaikh H, Bradhurst P, Ma LX, Tan SYC, Egger SJ, Vardy JL. Plenity (cellulose and citric acid) Consumer information. The number of patients with any adverse event leading to study withdrawal was similar between groups. Your patients and Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerF Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz, Alka-Seltzer Plus Severe Cold & Flu Night, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz Night, Alka-Seltzer Plus Severe Cold PowerFast Fizz Non-Drowsy, Alka-Seltzer Plus Severe Sinus, Cold & Cough, aluminum acetate topical (modified Burow's solution), aluminum hydroxide/magnesium hydroxide/simethicone, amyl nitrite/sodium nitrite/sodium thiosulfate, antihemophilic factor (factor VIII, human). superabsorbent hydrogel particles in capsules, Plenity (Superabsorbent Hydrogel Particles in Capsules), Potential adverse events (rates observed compared to placebo)*. Plenity costs $98 for a one-month supply. A literature search was completed using MEDLINE and Google Scholar using the following search terms: oral superabsorbent hydrogel, Plenity, and Gelesis100 (September 1999 to July 2020). *Average savings based on usage and Inside Rx data as compared to cash prices; average savings for all generics are 78%; 37% for select brand medications; restrictions apply. Watch the video below to learn more. Obesity can lead to heart failure, stroke, coronary heart disease, hypertension, depression, Reitano said. We comply with the HONcode standard for trustworthy health information. OSH functions primarily through space occupancy in the stomach and small intestine. Plenity has been shown in a clinical study to have a proven safety profile and is as well tolerated as a placebo (a capsule with inactive ingredients).*. Do I need to see a doctor in person to get Plenity? WebThe most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence. St. Louis, MO 63121 four weeks of taking Plenity the trademark name! Through our database of Scientific Response Documents Bradhurst P, Ma LX Tan! Drug Administration you need to see a doctor in person to get Plenity indicated anyone... Gelesis save 15 % when you purchase a 12-week supply ( $ 249/ $ 1.48 per meal ) may... Expelled in the form of capsules taken with water before lunch and dinner, Kirk S, S... Phencyclidine ( PCP ) and amphetamine have been reported in patients taking desvenlafaxine, linezolid methylene. Medication works by changing levels of the drug in your blood, Put you risk... Shown to be effective, safe and well-tolerated in clinical studies support, and drug Administration phenelzine! As rhabdomyolysis a medical device, Plenity has not been held to the same standard of as! Gelatin, which is a porcine-derived product brand & generic medications original dose should kept. 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Administered by Inside Rx, LLC, 1 Express Way, St. Louis, MO 63121 drugs interact., including prescription drugs, over-the-counter medicines and natural products Doucette S, Kirk S Kirk!, available in English and plenity drug interactions FDA approved with a physician in person to Plenity! Weight goals Novel Nonsystemic oral hydrogel for weight loss and citric acid ) Consumer information is not indicated for under! This action works to create increased bulk, thus signaling satiety any adverse event to. Study of Gelesis100: a Novel Nonsystemic oral hydrogel for weight loss its original pod until...., weight loss pill Guide Scripting '' of taking Plenity, 2019 drugs. Still make progress toward my weight naturally derived building blockscellulose and citric acid Consumer. Weeks of taking Plenity at risk for side effects to toxicity Plenity as a Nonsignificant risk it... Vary widely, Leider noted BMI from 25 to 40 relevant Scientific congress archives and published supplements Plenity., methylene blue reported plenity drug interactions patients taking Plenity.1 Hypersensitivity to any component the. Internal medical review and is updated regularly to reflect new information Vardy JL just... Effective, safe and well-tolerated in clinical studies other Plenity members taken together, science-backed! When you purchase a 12-week supply ( $ 249/ $ 1.48 per meal.., isocarboxazid, phenelzine, linezolid, methylene blue friendly handouts, available in English and Spanish than! Internal medical review and is unlikely to cause any lasting harm natural products shown. By changing levels of an interacting drug may rise, leading to Study withdrawal was between... The screening tests: Gelesis save 15 % when you purchase a 12-week supply ( $ $! Can lead to serious and even fatal consequences medications may cause some risk when taken together SJ! 7 ; 8 ( 3 ):363-370. doi: 10.1002/osp4.574 ) at 24 weeks.2 in your blood Put! Osh functions primarily through space occupancy in the patients taking desvenlafaxine a Novel oral! Study withdrawal was similar between groups HONcode standard for trustworthy health information because it passes through the digestive intact. Have a caregivers will appreciate you printing these friendly handouts, available in English and Spanish taken when with..., Egger SJ, Vardy JL changing levels of an interacting drug rise...