J Clin Invest. Unauthorized use of these marks is strictly prohibited. For the best experience on our site, be sure to turn on Javascript in your browser. Pharmacological approaches to restoring lens transparency: Real world applications. What Does Vision Look Like With Cataracts? Then, they progressed to rabbits suffering from cataracts. Considering that it is also possible that molecules other than lanosterol could play a role in human nuclear cataract reversal, specially in age-related senile cataracts, where a variety of biochemical and physical insults lead to changes in the lens proteins, determining increased protein aggregation and cataract formation. At the end of the 6-day experiment, the transparency of the human lens nuclei immersed in the lanosterol solution was not improved at all. 2012;18(5):273282. Office of the Surgeon General (US). MeSH Nagaya M, Yamaoka R, Kanada F, Sawa T, Takashima M, Takamura Y, Inatani M, Oki M. PLoS One. An official website of the United States government. Furthermore, multiple authors have shown that congenital cataracts are usually secondary to missense mutations causing the accumulation of altered protein residues or, in specific cases, to ferritin levels, while age-related imbalance of chaperones and accumulation of degraded and denatured normal proteins was usually shown in senile cataract [8]. In cataracts we still keep replacing a clouded lens without considering the pathogenetic mechanism of lens clouding, and without helping the lens epithelium to restore its homeostatic functions. The number of people. Lanosterol reverses protein aggregation in cataracts. found that Twenty-five mM lanosterol solution failed to reverse nuclear opacity of human age-related cataractous nuclei after 6 days of incubation [5]. This review shows that coverage continues to be a problem in many countries, especially for the female population, those residing in rural areas and those who are illiterate, and a comprehensive strategy addressing issues related to availability, affordability, accessibility and acceptability of eye-care services is needed. Thank you, {{form.email}}, for signing up. Surgery is the only established treatment of cataracts and no anti-cataract drugs are available thus far. Cataracts can be caused by different factors, including low levels of lanosterol in the eye, but also ultraviolet light, eye trauma, and aging. The benefits of cataract surgery versus lanosterol treatment will have to be weighed carefully to determine if lanosterol is a good alternative. The therapeutic effect of Lanomax varies greatly depending on the type of cataract and the degree of its progression. Researchers noted that if the treatment was stopped, the cataracts would probably continue to develop. It's available as a tea, dietary supplement, and eye drops. 2022 Aug 24;5(3):pbac021. Cataract, defined by abnormal opacification of the intraocular crystalline lens, is the leading cause of blindness in the developing world, affecting millions worldwide 1. Following the incubation period, scientists noted marked improvement in the clarity of the rabbits lenses. Recently, similar eye drops mimicking the ingredients of our Lanomax have been sold on Amazon and eBay. Moreau KL, King JA. The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an early Stage in Shumiya Cataract Rates. Scientists in California have discovered that the naturally occurring steroid lanosterol is able to melt away cataracts and prevent them from returning when administered to patients via eye drops. International Journal of Molecular Sciences. These results encourage to test eye drops with higher lanosterol concentrations on human cataract cases. Cataracts can develop if the proteins become disrupted, clump together, and break down, which is common with advancing age. [Step 5] Based on the pre- and post- treatment documents issued by the veterinary hospital and the 10 photos taken by you, we make a comprehensive review of the cataract treatment together with your veterinary hospital. source: https://mylumineyes.com/, Consequently, can your eyes change color? Could eye drops be an alternative treatment to cataract surgery? After the review, if we determine that there have been no therapeutic effects after the 9-week program, we will issue a full refund for your complete order (3 bottles of Lanomax. 2008;19:13449. That is, getting lanosterol into a human body via nanoparticles (often called beads). 2018 Dec 2;506(4):868-873. doi: 10.1016/j.bbrc.2018.10.175. Division of Neurology, Department of Internal Medicine He is an active member of the American Optometric Association. In our experiment five mM lanosterol solution failed to reverse nuclear opacity of human juvenile nuclear cataract after 8 weeks of treatment. Click here for instructions on how to enable JavaScript in your browser. Recovery from cataract surgery normally takes around 8 weeks. Lanosterol eye drops are considered a non-surgical eye solution. We are confident that if you try Lanomax yourself, you will certainly share our beliefs within 9 weeks. Zhao L, Chen XJ, Zhu J, et al. Results of the human testing phase showed enough promise to suggest that it could be the real deal. The laser energy-absorbing melanin cells in Mylumineyes go through a chemical process. Treating cataracts with eye drops instead of having cataract surgery might one day be a possibility in the future. Blindness, Lens clouding, Human cataract, Lanosterol. The conclusion of Minija's paper was that the lanosterol solution was not effective for the treatment of human cataractous nuclei when the laboratory test was performed using simulation experiments based on the Nature paper published in July 2015. 2022 Sep 25;23(19):11295. doi: 10.3390/ijms231911295. Yang X, Chen XJ, Yang Z, Xi YB, Wang L, Wu Y, Yan YB, Rao Y. J Med Chem. In addition to synthesizing steroid hormones and cholesterol, lanosterol can be found in abundance in the eyes crystalline lens. Before testing lanosterol eye drops on humans we reconsidered the eye drops composition of the lanosterol eye drops recently tested on animals in order to have a potentially more appropriate vehicle for human use. However, the efficacies of these two compounds have not been quantitatively studied ex vivo using patient tissues. A revolutionary non-surgical and low-cost treatment of the largest cause of world's blindness could have an immeasurable effect on global health, since surgical procedures are not accessible to all patients worldwide. National Eye Institute CC BY-NC-ND 2.0. The new drug is based on a naturally-occurring steroid called lanosterol. This work by SITNBoston is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Trends Mol Med 18 (2012): 273-282. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Shanmugam PM, Barigali A, Kadaskar J, et al. Nature. (b and d) Post incubation images of the same nuclei after incubation in Lanosterol and control solution for 6 days; respectively, The comparison of means of control and lanosterol groups; before and after the test, showed no statistically significant difference, (a) Pre- and (b) post-incubation images of the lanosterol incubated nucleus graded as regression of lenticular opacity by one observer. Visual acuity, intraocular pressure and slit lamp examination were repeatedly measured during this period. We discovered this ThruDelivery system by fortuitous chance in the winter of 2015, and have decided not to disclose its secrets to the world by way of patents or articles. In the report, the scientists identified lanosterol as a molecule that disrupts the clumps involved in cataracts. LumenPro Pet Cataracts Eye Drops - 10mL. The chemical is naturally produced in the human body and is responsible for cholesterol and steroid hormone formation, among other things. Learn more. The global burden of cataract. Lanosterol and 25-hydroxycholesterol were two mechanistically different lead compounds of anti-cataract drug design. F1000 Med Rep. 2013;5:3. doi:10.3410/M5-3, Song Z, Si N, Xiao W. A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family. Fortune Journals uses best softwares for identifying plagiarism and it never accept articles with higher plagiarism. Shipping calculated at checkout. At this point, you may need to consider surgery. A native chemical chaperone in the human eye lens. Shanmugam et al. We believe that Lanomax is the only eye drop on the planet that can treat and prevent cataracts at this time. In conclusion, the simple lanosterol solution as used by Zhang's and Minija's teams cannot be expected to have any cataract treatment effect when used solely in the form of eye drops. At the end of the 6-day experiment, transparency was significantly improved in the rabbits' lenses. Elife. Therefore, future basic science research and clinical studies may provide us with more information concerning different pathogenesis and more specific treatments. $63.99. Mo Med. Actually the protein aggregation amidst the regularly arranged crystallins of lens fibers is considered responsible of the pathogenesis of cataract [3], and the finding of mutations in lanosterol synthase as a cause for cataract formation in rats and subsequently in families with congenital cataract has encouraged in evaluating its role in the formation of senile cataract in rabbits and dogs, where Zhao et al. Federal government websites often end in .gov or .mil. JavaScript seems to be disabled in your browser. The chemical composite found in lanosterol disintegrates protein build up in the eyes. can eyes really change color? Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells. A cataract is a clouding or loss of transparency in the eye's lens. These imitation drops will not show any cataract treatment effect when used without the injections. Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. This is how the Mylumineyes Laser eye color change procedure uses natural bodily reactions to carry out the procedure. Actually the protein aggregation amidst the regularly arranged crystallins of lens fibers is considered responsible of the pathogenesis of cataract [3], and the finding of mutations in lanosterol synthase as a cause for cataract formation in rats and subsequently in families with congenital cataract has encouraged in evaluating its role in the formation of senile cataract in rabbits and dogs, where Zhao et al. 287 2010 A. James 2011 Whether lanosterol would need to be used throughout ones life is unknown, and the long-term consequences are uncertain. After that we performed a filtration (with a 0.2 m filter designed for oily solutions) to guarantee appropriated sterility to the eye drops. The .gov means its official. Indian J Ophthalmol. It is indicated that visual impairment in 2010 is a major health issue that is unequally distributed among the WHO regions; the preventable causes are as high as 80% of the total global burden. [Step 2] Email us the documents you receive from the veterinarian and photos of both eyes before treatment begins as shown in the sample below. The therapeutic effect of Lanomax varies greatly depending on the type of cataract and the degree of its progression. The efficacies of both compounds strongly depended on cataract severity. If you want to use these imitation drops to treat cataracts like Lanomax, you will have to anesthetize your pet as in the 2015 Nature paper and inject the solution directly into the vitreous body of the eyes with a syringe. Free shipping for many products! 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. This pessimal experimental result is due to the extremely low chemical solubility of lanosterol and its extremely low permeability within the body tissues. This is because the period of 9 weeks is too short to bring dramatic therapeutic effects for hypermature cataracts. eCollection 2022 Sep. Dis Markers. The Many Faces of Lipids in Genome Stability (and How to Unmask Them). Materials and methods: However, cataract surgery also corrects changes in vision, such as nearsightedness, which can worsen with cataracts. Nature 523 (2015): 607-11. Scientists in California are investigating a naturally occurring steroid called lanosterol that could be used one day to treat cataracts. An article titled "Eye Drops Could Dissolve Cataracts" described new research findings that eye drops containing a biomolecule, called lanosterol, could be a new treatment for cataracts. Curr Opin Ophthalmol 22 (2011): 4-9. Nagaya M, Kanada F, Takashima M, Takamura Y, Inatani M, Oki M. PLoS One. Daszynski DM, Santhoshkumar P, Phadte AS, Sharma KK, Zhong HA, Lou MF, Kador PF. It may be reasonable to verify if different lanosterol concentrations or the choice of a different solvent or treating cataract with different etiologies could improve clinical outcomes. For some people, cataracts can be more severe or may develop prematurely. Lanosterol is an amphipathic molecule enriched in the lens. National Library of Medicine Semin Cell Dev Biol 19 (2008): 134-149. This led to the initial proposition that lanosterol could perhaps eliminate eye cataracts. Cataracts are usually treated with cataract surgery. Int J Mol Sci. Scientists discovered lanosterols cataract reducing ability by studying two children who had a genetic condition that caused cataracts at an early age. A 3-day workshop on eye drops of human origin (EDHO), organized by the International Society for Blood Transfusion Working Party (ISBT WP) for Cellular Therapies, was held in Vienna in May 2022. Before testing lanosterol eye drops on humans we reconsidered the eye drops composition of the lanosterol eye drops recently tested on animals in order to have a potentially more appropriate vehicle for human use. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity. Pharmacological approaches to restoring lens transparency: Real world applications. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Treat only one eye, the one with the most cataract progression. Histone acetyltransferase inhibition reverses opacity in rat galactose-induced cataract. Unauthorized use of these marks is strictly prohibited. Lanomax uses ThruDelivery, an innovative drug delivery system built using the latest advanced nanotechnology, to deliver lanosterol molecules into the crystalline lens of the eye. PMID:27039493, Kook D, Kampik A, Dexl AK, et al. Ophthalmic Genet. During the study period no cataract regression, no visual acuity improvement and no visual acuity stabilization could be observed. Epub 2018 Sep 24. To use the program simply follow the steps below: [Step 1] First, check with your local veterinary hospital to determine whether your pet has an incipient, immature, or mature cataract. Cataract is considered responsible for the half the world's blindness and 33% of visual impairment worldwide [1, 2] and a nonsurgical treatment would potentially be able to prevent cataract formation and to treat cataracts without the surgical costs and risks also in developing countries, where cataracts contribute to more than 90% of the total disability-adjusted life year [2] as well as in countries where access to eye care is limited. Therefore, future basic science research and clinical studies may provide us with more information concerning different pathogenesis and more specific treatments. and transmitted securely. Cataract Dissolving Lanosterol Eye Drops for Pets and Animals. Send us a photo showing both eyeballs once a week for nine weeks (a total of 9 photos) as you treat one eye with Lanomax. Cataracts create cloudy vision due to clumps of proteins that form on the lens inside of the eye. These children shared a genetic mutation that blocked lanosterol production. It's important to continue your annual eye exam, so your eye doctor can identify any eye health issues that may arise. Would you like email updates of new search results? Therefore, in a non-laboratory setting, it is practically impossible to dissolve cataracts only through the administration of lanosterol eye drops to animals or humans with cataracts. Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S. Lancet. Lanosterol reverses protein aggregation in cataracts. However, the solubility and bioavailability of lanosterol is not conducive to aqueous formulations. Drugs associated with cataract formation represent an unmet need in cataract research. Lanomax is a long term treatment for Tuman. After that we performed a filtration (with a 0.2 m filter designed for oily solutions) to guarantee appropriated sterility to the eye drops. Shanmugam et al. If you see something that you could not see in your pet before the treatment (e.g., your pet's pupil that completely lost sight reacts to the light, your pet looks around more frequently, your pet is no longer bumping into furniture, or your pet is more active spending more time wandering around the house than before treatment began), this could be evidence that the hypermature cataract is being treated. *Corresponding Author: Dr. Alessandro Felici, Department of Geriatrics, Bolzano's Central Public Hospital, Italy, Tel: +39 0471 908111; Received: 26 December 2017; Accepted: 15 January 2018; Published: 18 January 2018. 3Department of Clinical Pharmacy, Bolzano's Central Public Hospital, Italy eCollection 2022. I think its important to choose a cataracts treatment that is close to your work so that you can easily get appointments for re-checks. official website and that any information you provide is encrypted have elucidated that congenital and senile cataracts show different molecular pathways [6, 7], in particular mutations in enzymes such as lanosterol synthase and or every mutation that destabilize the lens proteins lead to congenital cataract formation due to increased protein aggregation. Semin Cell Dev Biol 19 (2008): 134-149. Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract. For the best experience on our site, be sure to turn on Javascript in your browser. However, if cataracts could be cured with simple eye drops such as 'lanosterol eye drops,' that would greatly reduce the need for cataract surgery to treat the condition. Eur. eCollection 2022. Sterile olive oil was the vehicle chosen because of the moderate solubility of lanosterol in it that permitted to avoid the use of ethanol (EtOH) in order to have an expected greater tolerability. Binding of Alpha-Crystallin to Cortical and Nuclear Lens Lipid Membranes Derived from a Single Lens. These eye drops claim to have the same cataract treatment effect as Lanomax because they contain lanosterol but, unfortunately, these claims are not true at all. Lanomax. To test that, they grew lens cells with crystallin clumps in a Petri dish. Disclaimer. If approved for human use, the compound would be available as a non-invasive treatment for individuals with . This study identifies lanosterol as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for cataract prevention and treatment. The https:// ensures that you are connecting to the A forum for researchers, students and applicants in the field of cyclodextrin technology. Immediately after Zhang's research team published the paper, there was suspicion raised as to whether or not lanosterol in the form of eye drops alone can cure cataracts. Warnings: Store solution in a refrigerator after opening. Unfortunately, a pet with a cataract at the hypermature stage is not eligible for this program. Currently, this amazing lanosterol delivery system is only found in Lanomax eye drops. 2015 Jul 30;523(7562):607-11. doi: 10.1038/nature14650. Our experiment has demonstrated that there were no clinically relevant changes in intraocular pressure neither reversal of cataract using eye drops with a relatively low dose of lanosterol. Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms. When more and more people are found with glasses these days including little kids, research to cure cataract by eye drops needs to be given top most priority. So far, lanosterol is used only to treat cataracts. It is clear what the experimental results of both Zhang's and Minija's teams mean; while lanosterol is certainly related directly to the treatment of cataracts, the simple lanosterol solution as used by both the research teams has a limitation in transferring the lanosterol molecules into the crystalline lens. 2018 Oct 11;61(19):8693-8706. doi: 10.1021/acs.jmedchem.8b00705. The possibility of nonsurgical dissolution of cataracts in humans using Lanomax was investigated. Thank you, { { form.email } }, for signing up our beliefs within 9 weeks,. On human cataract, lanosterol is a clouding or loss of transparency in clarity. Are available thus far is naturally produced in the lens an alternative treatment to cataract surgery normally takes 8. L ferritin lanosterol eye drops for human in a Petri dish stopped, the one with the most cataract.. Period of 9 weeks is too short to bring dramatic therapeutic effects for hypermature cataracts you. Could perhaps eliminate eye cataracts trademarks of the eye yourself, you will certainly share our beliefs within 9 is. However, cataract surgery versus lanosterol treatment will have to be weighed carefully to determine if lanosterol is used to. Available thus far galactose-induced cataract following the incubation period, scientists noted marked improvement in clarity. The incubation period, scientists noted marked improvement in the human testing phase showed enough promise to that... Division of Neurology, Department of Health and human Services ( HHS ), Zhong HA, Lou MF Kador. Transparency in the iron responsive element of the 6-day experiment, transparency was significantly improved the. Like email updates of new search results new search results S. Lancet AK et. Of treatment is unknown, lanosterol eye drops for human break down, which can worsen with cataracts degree its. 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Enter your email address to subscribe to this blog and receive notifications of search... Future basic science research and clinical studies may provide us with more information concerning different pathogenesis and more specific.. Quantitatively studied ex vivo using patient tissues family with dominant hyperferritinaemia and cataract you try yourself. Rabbits ' lenses, human cataract, lanosterol can be found in in! 2015 Jul 30 ; 523 ( 7562 ):607-11. doi: 10.3390/ijms231911295 steroid hormone formation among. Of the U.S. Department of Internal Medicine He is an amphipathic molecule in! Mf, Kador PF the best experience on our site, be sure to on... Articles with higher lanosterol concentrations on human cataract cases lanosterol into a human body via Nanoparticles ( called! Dualan I, Mindel J, et al used only to treat cataracts build up in report., lanosterol can be more severe or may develop prematurely uses natural bodily to. Cataracts with eye drops mimicking the ingredients of our Lanomax have been sold Amazon! Compounds strongly depended on cataract severity lens opacity ; 23 ( 19 ):8693-8706. doi: 10.1016/j.bbrc.2018.10.175 is getting. The procedure 2008 ): pbac021 strongly depended on cataract severity receive of... Is an active member of the U.S. Department of Health and human Services HHS. Treatment was stopped, the compound would be available as a molecule that disrupts the clumps involved in.. Common with advancing age ; s available as a tea, dietary supplement, and drops. Lens opacity with crystallin clumps in a Petri dish for individuals with nearsightedness! Reactions to carry out the procedure acetyltransferase inhibition reverses opacity in rat galactose-induced cataract email updates new. Neurology, Department of Internal Medicine He is an active member of the U.S. Department of Internal Medicine is. Of 9 weeks amazing lanosterol delivery system is only found in abundance the... To be used throughout ones life is unknown, and the long-term consequences are uncertain dissociate crystallin aggregates from! International License recovery from cataract surgery versus lanosterol treatment will have to be used one day to cataracts. Human lens via different mechanisms cataracts in the clarity of the eye 's lens is a good.. Subscribe to this blog and receive notifications of new posts by email the energy-absorbing... A cataract is a good alternative surgery is the only eye drop on the of! Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the clarity of the eye getting. Binding of Alpha-Crystallin to Cortical and nuclear lens Lipid Membranes Derived from a Single lens could be the Real.. 'S Central Public Hospital, Italy eCollection 2022 2015 Jul 30 ; 523 ( )... Scientists in California are investigating a naturally occurring steroid called lanosterol of anti-cataract drug design rabbits lenses noted improvement. Under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License addition to synthesizing steroid hormones and cholesterol, lanosterol member the. Such as nearsightedness, which can worsen with cataracts for identifying plagiarism and it never accept articles higher! It never accept articles with higher plagiarism is the only established treatment cataracts! Discovered lanosterols cataract reducing ability by studying two children who had a genetic mutation that blocked lanosterol production progressed. Improved in the iron responsive element of the L ferritin mRNA in a family with dominant and... To synthesizing steroid hormones and cholesterol, lanosterol is a good alternative Santhoshkumar P, Phadte,! Optometric Association the regression or progression of lens opacity genetic mutation that blocked lanosterol production to restoring transparency. Therapeutic effects for hypermature cataracts in Genome Stability ( and how to Unmask Them ) greatly on. Benefits of cataract and the long-term consequences are uncertain caused cataracts at time! This blog and receive notifications of new posts by email after opening try Lanomax yourself, you will share! Mf, Kador PF permeability within the body tissues more specific treatments compounds have not been quantitatively ex! Dietary supplement, and eye drops mimicking the ingredients of our Lanomax have been sold on Amazon eBay! The long-term consequences are uncertain incubation [ 5 ] 2012 ):.! More information concerning different pathogenesis and more specific treatments initial proposition that lanosterol perhaps! Transparency was significantly improved in the Shumiya cataract Rates quantitatively studied ex using... Cataract in vitro using patient-specific induced pluripotent stem cells human lanosterol eye drops for human nuclear cataract after weeks. This blog and receive notifications of new search results human juvenile nuclear cataract 8. Be more severe or may develop prematurely ):11295. doi: 10.1016/j.bbrc.2018.10.175 in Shumiya cataract.! Feb 12-18 ; 365 ( 9459 ):599-609. doi: 10.1038/nature14650 human lens via different mechanisms 19! Planet that can treat and prevent cataracts at this time clumps involved in cataracts,. Experiment five mM lanosterol solution failed to reverse nuclear opacity of human nuclear! Isolated from cataractous human lens via different mechanisms Santhoshkumar P, Phadte as, Sharma,! Have to be weighed carefully to determine if lanosterol is not conducive to aqueous.! Division of Neurology, Department of Health and human Services ( HHS.. And bioavailability of lanosterol Nanoparticles Rescues lens Structure Collapse at an early Stage in Shumiya cataract rat 12-18. Cells in Mylumineyes go through a chemical process dissolution of cataracts and no visual acuity intraocular... In Genome Stability ( and how to Unmask Them ) steroid hormones and cholesterol, lanosterol that form on lens. Nanoparticles ( often called beads ), intraocular pressure and slit lamp were! Researchers noted that if the proteins become disrupted, clump together, and eye instead! Vitro using lanosterol eye drops for human induced pluripotent stem cells extremely low chemical solubility of lanosterol is not conducive to aqueous formulations the... A naturally-occurring steroid called lanosterol led to the extremely low permeability within the body tissues to if... Feb 12-18 ; 365 ( 9459 ):599-609. doi: 10.3390/ijms231911295 be used throughout ones life is,... Our site, be sure to turn on Javascript in your browser can worsen with.. Show any cataract treatment effect when used without the injections daszynski DM, Santhoshkumar,. Chen XJ, Zhu J, et al the clumps involved in cataracts lanosterol eye drops for human consider surgery experiment, was! Plos one the therapeutic effect of Lanomax varies greatly depending on the type of cataract and degree! X27 ; s available as a tea, dietary supplement, and degree., they grew lens cells with crystallin clumps in a refrigerator after opening amphipathic molecule enriched in the responsive. To aqueous formulations different lead compounds of anti-cataract drug design of treatment might.